The Expression of Angiopoietin-1 and −2 in the Endometrium of Women with Abnormal Bleeding Induced by an Intra-Uterine Device
作者: HL QianHF WangML Yang
作者单位: 1Department of Gynaecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
2Reproductive Centre, The Central Hospital of Taian, Shandong, China
刊名: Journal of International Medical Research, 2010, Vol.38 (1), pp.100-110
来源数据库: Sage Publications, Inc.
DOI: 10.1177/147323001003800112
关键词: Intra-uterine deviceAbnormal uterine bleedingAngiopoietinAngiotensin-1Angiotensin-2Endothelial cell-specific tyrosine kinase receptor-2 (Tie-2)Reverse transcription-Polymerase chain reaction (RT-PCR)Immunohistochemistry
原始语种摘要: This study identified differences in expression of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) in the endometrium of 33 women with abnormal bleeding induced by an intra-uterine device (IUD; 23 proliferative phase, 10 secretory phase) compared with 28 control samples from normal endometria in women without an IUD fitted (12 proliferative phase, 16 secretory phase). Expression of Ang-1, Ang-2 and endothelial cell-specific tyrosine kinase receptor-2 (Tie-2) mRNA was detected by reverse transcription-polymerase chain reaction (RT-PCR), and Ang-1 and Ang-2 protein levels were detected by immunohistochemistry. The RT-PCR results showed significantly decreased Ang-1 expression in the endometrium from IUD patients during both phases compared with the control women. Expression of Tie-2 mRNA...
全文获取路径: Sage国际出版集团  (合作)
影响因子:0.958 (2012)

  • uterine 子宫的
  • endometrium 子宫内膜
  • women 妇女
  • abnormal 异常的
  • transcription 地名转写
  • protein 蛋白质
  • compared 肿瘤和正常组织细胞周期的比较
  • bleeding 模糊不清
  • tyrosine 酪氨酸
  • mRNA m核糖核酸