Minocycline as an adjunct for treatment-resistant depressive symptoms: A pilot randomised placebo-controlled trial
作者: Muhammad I HusainImran B ChaudhryNusrat HusainAmeer B KhosoRaza R RahmanMunir M HamiraniJohn HodsollInti QurashiJohn FW DeakinAllan H Young
作者单位: 1Camden and Islington NHS Foundation Trust, London, UK
2Pakistan Institute of Living and Learning, Karachi, Pakistan
3University of Manchester, Manchester, UK
4Dow University of Health Sciences, Karachi, Pakistan
5Abbasi Shaheed Hospital, Karachi, Pakistan
6Institute of Psychiatry, King’s College London, London, UK
7Mersey Care NHS Foundation Trust, Liverpool, UK
刊名: Journal of Psychopharmacology, 2017, Vol.31 (9), pp.1166-1175
来源数据库: Sage Publications, Inc.
DOI: 10.1177/0269881117724352
关键词: Inflammationdepressionminocycline
原始语种摘要: Background:(#br)Evidence suggests that anti-inflammatory medication may be effective in the treatment of depressive symptoms. In this study, we aimed to investigate whether minocycline added to treatment as usual (TAU) for 3 months in patients with treatment-resistant depression will lead to an improvement in depressive symptoms.(#br)Methods:(#br)Multi-site, 12-week, double-blind, placebo-controlled, pilot trial of minocycline added to TAU for patients suffering from DSM-5 major depressive disorder, whose current episode has failed to respond to at least two antidepressants. The primary outcome measure was mean change in Hamilton Depression Rating Scale (HAMD-17) scores from baseline to week 12. Secondary measures were the Clinical Global Impression scale (CGI), Patient Health...
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关键词翻译
关键词翻译
  • depressive 降低的
  • adjunct 代数余子式
  • resistant 耐久的
  • placebo 无效对照药
  • pilot 驾驶员
  • controlled 受控
  • trial 试验
  • treatment 处理