Expression of the Epithelial Marker E-Cadherin by Thyroid C Cells and Their Precursors During Murine Development
作者: Yoko KamedaToshiyuki NishimakiOsamu ChisakaSachiko IsekiHenry M. Sucov
作者单位: 1Department of Anatomy, Kitasato University School of Medicine, Kanagawa, Japan
2Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
3Section of Molecular Craniofacial Embryology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
4Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California
刊名: Journal of Histochemistry & Cytochemistry, 2007, Vol.55 (10), pp.1075-1088
来源数据库: Sage Publications, Inc.
DOI: 10.1369/jhc.7A7179.2007
关键词: ultimobranchial bodythyroid C cellsfourth pharyngeal pouchendothelial marker E-cadherinneural crest cellsconnexin43-lacZ transgenic miceWnt1-Cre/R26R double-transgenic mice
原始语种摘要: Studies of chick–quail chimeras have reported that avian ultimobranchial C cells originate from the neural crest. It has consequently been assumed, without much supporting evidence, that mammalian thyroid C cells also originate from the neural crest. To test this notion, we employed both Connexin43-lacZ and Wnt1-Cre/R26R transgenic mice, because their neural crest cells can be marked. We also examined the immunohistochemical expression of a number of markers that identify migratory or postmigratory neural crest cells, namely, TuJ1, neurofilament 160, nestin, P75NTR, and Sox10. Moreover, we examined the expression of E-cadherin, an epithelial cell marker. At embryonic day (E)10.5, the neural crest cells densely populated the pharyngeal arches but were not distributed in the pharyngeal...
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