Correlating Labeling Chemistry and in-vitro Test Results with the Biological Behavior of Radiolabeled Proteins<sup> * </sup>
作者: Suresh C. SrivastavaGeorge E. Meinken
作者单位: 1Medical Department Brookhaven National Laboratory Upton, New York, U.S.A.
刊名: The International Journal of Biological Markers, 1986, Vol.1 (3), pp.111-120
来源数据库: Sage Publications, Inc.
DOI: 10.1177/172460088600100301
关键词: Monoclonal antibodiesProteinsLabeling chemistryIn-vivo behavior
原始语种摘要: A study of the effect of various rediochemical labeling parameters on the in-vivo behavior of proteins, in particular of monoclonal antibodies, was carried out. Both radioiodination, and radiometal labeling (using protein-chelating agent conjugates), of antimelanoma, antiplatelet, and anticolon carcinoma monoclonal antibodies (222.28s, 7E3, and GA-733 respectively), as well as the direct labeling of human serum albumin with 99m Tc, were investigated. Different aspects of the biological behavior are affected in relation to the labeling chemistry involved. These include the immunoreactivity, blood clearance and tissue uptake kinetics, and rates and routes of excretion. Individual radionuclide effects have often to be addressed separately. Some antibodies are more susceptable to...
全文获取路径: Sage国际出版集团  (合作)

  • sup 吃晚饭
  • effects 海员自身物品
  • kinetics 动力学
  • biological 生物学的
  • necessary 必要的
  • monoclonal 单细胞系的
  • labeling 加标
  • conditions 条件式
  • various 千变万化的
  • radionuclide 放射性核素