1,5-Benzothiazepine: Bioactivity and targets
作者: Rajneesh KaurRaman SinghKuldeep Singh
作者单位: 1Chemistry Department, MMEC, M. M. University, Mullana – 133207, India
刊名: Chemical Biology Letters, 2016, Vol.3 (1), pp.18-31
来源数据库: Integrated Science Publishing
关键词: 15-benzothiazepineVasodilatorAntiplatelet aggregationAnticholinesterase inhibitorGlycogen synthasekinase-3β inhibitorsMitogen-Activated Protein kinase protein inhibitors
原始语种摘要: 1,5-Benzothiazepine nucleus is present in a number of clinically used drugs such as diltiazem, clentiazem, thiazesim, quetiapine, and clothiapine. 1,5-Benzothiazepine can be easily introduced in the molecule having 2-aminothiophenol moiety. This article considers various targets for 1,5-benzothiazepine nucleus to establish structural activity relationship. It is an attempt to compile account of various structural modification in 1,5-benzothiazepine scaffold as reported for their versatile biological activities. This review would provide a platforms for selection of suitable moieties and development of specific chemical entities with desired features.

  • various 千变万化的
  • suitable 合适的
  • relationship 关系
  • biological 生物学的
  • clothiapine 氯噻平
  • chemical 化学的
  • easily 容易地
  • introduced 引种的
  • activity 活度
  • present 出席的