Mixed Ligand Complexes with 4-Aminoantipyrine Derivatives to Combat Natural Antioxidant System: Synthesis, Characterization and Biological Studies
作者: J. JosephG. Ayisha Bibin Rani
刊名: Asian Journal of Chemistry, 2015, Vol.27 (3)
来源数据库: Asian Journal of Chemistry
DOI: 10.14233/ajchem.2015.17108
关键词: 4-AminoantipyrineMixed ligand complexViscosityDNA bindingAntioxidant activityAntimicrobial activity
原始语种摘要: Novel 4-aminoantipyrine based mixed ligand metal complexes with the Schiff bases of L1 (L1- 4-aminoantipyrine with furfuraldehyde and L2/L3/L4/L5 are and L2-2-aminophenol with salicylaldehyde, L3-2-aminophenol with cinnamaldehyde, L4-2-aminobenzothiazole with salicylaldehyde, L5-2-aminobenzothiazole with cinnamaldehyde) were synthesized. The structures of the mixed ligand complexes were established by analytical and spectral techniques. They were screened for in vitro antimicrobial activity against of bacteria and fungi by disc diffusion method. The interaction of metal complexes with calf thymus-DNA (CT-DNA) was investigated by UV-visible, cyclic voltammetry, viscosity and thermal denaturation studies. DNA interaction studies suggest that metal complex binds to calf thymus-DNA through...
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  • complex 超群
  • activity 活度
  • aminophenol 氨基苯酚
  • metal 金属
  • furfuraldehyde 呋喃甲醛
  • diphenyl 联二苯
  • picryl 苦基
  • antioxidant 抗氧化剂
  • studied 学习
  • thymus 胸腺