Determination of 5-Fluorouracil in its Injection and Biological Fluid by Enhanced Chemiluminescence Based on Luminol-Ag(III) Complex Reaction in Alkaline Solution
作者: Ya-Juan Dong Ting Wang Pei-Yun ChenHan-Wen Sun
刊名: Asian Journal of Chemistry, 2015, Vol.27 (3)
来源数据库: Asian Journal of Chemistry
DOI: 10.14233/ajchem.2015.17120
关键词: Enhanced chemiluminescenceFlow injection5-FluorouracilPharmaceutical analysis.
原始语种摘要: A novel chemiluminescence method was developed for the determination of 5-fluorouracil based on the chemiluminescence reaction between Ag(III) complex [Ag(HIO6)2]5- and luminol in alkaline solution. Chemiluminescence emission of [Ag(HIO6)2]5--luminol in alkaline medium was different from that in acidic medium. A possible mechanism of enhanced chemiluminescence emission was suggested. The enhanced effect of 5-fluorouracil on chemiluminescence emission of the [Ag(HIO6)2]5--luminol system was found. The effect of the reaction conditions on chemiluminescence emission was examined and optimized. The chemiluminescence intensity was proportional to the logarithm of 5-fluorouracil concentration with correlation coefficient (r) of 0.9954 in the range of 10-5000 ng/mL. Under the optimized...
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  • luminol 鲁米诺
  • reaction 反酌
  • injection 贯入
  • Injection 喷射注射注频(把信号加到电路或电子管)(卫星)射入轨道
  • emission 发射
  • determination 测定
  • detection 探测
  • fluorouracil 氟尿嘧啶
  • pharmaceutical 
  • sensitivity 灵敏度