In silico Analysis of Single Nucleotide Polymorphisms (Snps) in Human FTO Gene
作者: Marwa Mohamed Osman
刊名: JSM Bioinformatics, Genomics and Proteomics, 2016, Vol.1 (1)
来源数据库: JSciMed Central Journals
关键词: Fat mass and obesity associated protein (FTO) geneSNPsmiRNA site3’UTRBioGriD
原始语种摘要: Obesity is a common and serious medical problem that adverse health consequences and associated with many serious disease. FTO gene plays a main role in obesity. Bioinformatics’ analysis of FTO gene initiated by Polyphen-2 and SIFT server was used to review 31pathological polymorphisms. Among these 31, 10 pathological polymorphisms were found to be very damaging, with higher Polyphen-2 score of the Polyphen-2 server (=1) and a SIFT tolerance index of 0.000-0.005. Protein structural analysis was done by modeling of amino acid substitutions using Project Hope server for all these pathological polymorphisms. 30 SNPs in the 3’URT containing 63 alleles can be disrupted by a conserved miRNA site. Hence, we hope our results will provide useful information that needed to help researchers to do...
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  • obesity 肥胖
  • pathological 病理学的
  • disrupted 断线状
  • further 进一步
  • serious 认真的
  • higher 
  • analysis 分析
  • these 这些的
  • server 服务程序
  • problem 题目