New uses and formulations of glucagon for hypoglycaemia
作者: Pilar I Beato-Víbora PhD, Francisco J Arroyo-Díez PhD
刊名: Drugs in Context, 2019
来源数据库: BioExcel Publishing Ltd
DOI: 10.7573/dic.212599
关键词: Type 1 diabetesGlucagonNasal glucagonHypoglycaemiaDual-hormone artificial pancreasExerciseMini-dose glucagonInjectable glucagon
原始语种摘要: Hypoglycaemia is the more frequent complication of insulin therapy and the main barrier to tight glycaemic control. Injectable glucagon and oral intake of carbohydrates are the recommended treatments for severe and non-severe hypoglycaemia episodes, respectively. Nasal glucagon is currently being developed as a ready-to-use device, to simplify severe hypoglycaemia rescue. Stable forms of liquid glucagon could open the field for different approaches for mild to moderate hypoglycaemia treatment, such as mini-doses of glucagon or continuous subcutaneous glucagon infusion as a part of dual-hormone closed-loop systems. Pharmaceutical companies are developing stable forms of native glucagon or glucagon analogues for that purpose.
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关键词翻译
关键词翻译
  • glucagon 高血糖素
  • hypoglycaemia 低血糖
  • hormone 激素
  • subcutaneous 皮下的
  • diabetes 糖尿病
  • insulin 胰岛素
  • intake 收气
  • recommended 推荐
  • tight 密实的
  • barrier 堡坝