Ontogeny and Plasticity of Adult Hippocampal Neural Stem Cells
作者: Sieber-Blum M.
刊名: Developmental Neuroscience, 2003, Vol.25 (2–4), pp.273-278
来源数据库: Karger
DOI: 10.1159/000072274
关键词: HippocampusStem cellWnt1Wnt1-creNeural crestROSA 26R26RChondrocyteSmooth muscle cellPigment cellMelanocyte
原始语种摘要: We have investigated the ontogenetic origin and the degree of plasticity of adult hippocampal neural stem cells. Wnt1-expressing cells are located at the dorsal aspect of the embryonic neural tube and some of them are predestined to give rise to neural crest stem cells. Whereas the majority of adult hippocampal neural stem cells do not originate from cells that express Wnt1, a subset does express Wnt1 transiently during embryogenesis, as determined in the double transgenic mouse, Wnt1-cre/R26R. Hippocampal stem cells from adult ROSA 26 mice differentiate into chondrocytes, melanocytes (pigment cells) and smooth muscle cells when cocultured with neural crest cells from quail embryos. Neural crest cell-generated stimuli have a short-range of action and are recognized across species. These...
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影响因子:3.413 (2012)

  • adult 成体
  • cells 麻风细胞
  • crest 
  • differentiate 微分
  • pigment 色素
  • plasticity 可塑性
  • ontogenetic 个体发生的
  • neural 神经系统的
  • remarkably 显著地
  • muscle 肌肉