A Novel Permutation Testing Method Implicates Sixteen Nicotinic Acetylcholine Receptor Genes as Risk Factors for Smoking in Schizophrenia Families
作者: Faraone St.V.Su J.Taylor L.Wilcox M.Van Eerdewegh P.Tsuang M.T.
刊名: Human Heredity, 2004, Vol.57 (2), pp.59-68
来源数据库: Karger
DOI: 10.1159/000077543
关键词: AcetylcholineLinkageNicotinic receptorGeneticsPermutation testingCandidate genes
原始语种摘要: Smoking is a common correlate of schizophrenia, which leads to medical morbidity. Although twin and adoption studies have consistently implicated genes in the etiology of both smoking and schizophrenia, finding genes has been difficult. Several authors have suggested that clinical or neurobiological features associated with schizophrenia, such as smoking, might improve the ability to detect schizophrenia susceptibility genes by identifying genes related to the etiology of that feature. The objective of this study is to assess evidence for linkage of sixteen nicotinic acetylcholine receptor genes and smoking in schizophrenia families, using data from the NIMH Genetics Initiative for schizophrenia. Sixteen nicotinic acetylcholine receptor genes were selected prior to analysis. We used a...
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影响因子:1.569 (2012)

  • schizophrenia 精神分裂症
  • schizophrenic 精神分裂症
  • smoking 抽烟
  • candidate 选择物
  • acetylcholine 乙酰胆碱
  • marginally 在边上
  • hypothesis 假说
  • permutation 置换
  • linkage 连接
  • receptor 接受体