The Role of Glutamate in the Locus Coeruleus during Opioid Withdrawal and Effects of H-7, a Protein Kinase Inhibitor, on the Action of Glutamate in Rats
作者: Tokuyama S.Zhu H.Wakabayashi H.Feng Y.Z.Ho I.K.
刊名: Journal of Biomedical Science, 1998, Vol.5 (1), pp.45-53
来源数据库: Karger
DOI: 10.1159/000025311
关键词: MorphineButorphanolDependencephysicalGlutamateLocus coeruleusMicrodialysisProtein kinases
原始语种摘要: To investigate the role of glutamate in the locus coeruleus (LC) during opioid withdrawal, rats were continuously infused with morphine (a µ-opioid receptor agonist, 26 nmol/µl/h) or butorphanol (a µ/δ/κ-mixed opioid receptor agonist, 26 nmol/µl/h) intracerebroventricularly (i.c.v.) via osmotic minipumps for 3 days. A direct LC injection of glutamate (1 or 10 nmol/5 µl) or naloxone (an opioid receptor antagonist, 24 nmol/5 µl) induced withdrawal signs in morphine- or butorphanol-dependent animals. However, these agents failed to precipitate any withdrawal signs in saline-treated control animals. On the other hand, the expression of withdrawal signs precipitated by the administration of glutamate or naloxone in opioid-dependent animals was completely blocked by concomitant...
全文获取路径: PDF下载  Karger  (合作)
影响因子:2.458 (2012)

  • opioid 鸦片样物质
  • butorphanol 布托啡诺
  • morphine 吗啡
  • withdrawal 取消
  • protein 蛋白质
  • naloxone 纳洛酮
  • infusion 浸剂
  • precipitated 沉淀的
  • kinase 激酶
  • microdialysis 微量渗析