Muscular Dystrophy: Centronucleation May Reflect a Compensatory Activation of Defective Myonuclei
作者: Totsuka T.Watanabe K.Uramoto I.Sakuma K.Mizutani T.
刊名: Journal of Biomedical Science, 1998, Vol.5 (1), pp.54-61
来源数据库: Karger
DOI: 10.1159/000025312
关键词: Muscular dystrophyCentral nucleiAvian muscleInflammationDwarfismLymphocyteMechanochemical transducerBoneSteroidFiber splitting
原始语种摘要: Muscular dystrophy has long been believed to be characterized by degeneration and abortive regeneration of muscle fibers (the muscle degeneration theory), but unfortunately its pathogenesis is still unclear and an effective treatment has yet to be developed. As a challenge to the theory, we have proposed an alternative muscle-defective-growth theory and a further bone muscle growth imbalance hypothesis supposing possible defects in bone-growth-dependent muscle growth based on our findings in hereditary dystrophic dy mice (C57BL/6J dy/dy ). This review presents some new insights into the pathogenesis of the disease along with our hypothesis, focusing on the physiological meaning of centronucleation, one of the major pathological changes commonly observed in dystrophic muscles of man and...
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影响因子:2.458 (2012)

  • muscle 肌肉
  • regeneration 再生
  • hypothesis 假说
  • dystrophy 营养障碍
  • growth 生长
  • dystrophic 似营病养不良
  • pathogenesis 发病机理
  • unclear 不清楚的
  • abortive 龙的
  • alternative 可选择的