Molecular Profiling of Tyrosine Kinases in Normal and Cancer Cells
作者: Kung H.-J.Chen H.-C.Robinson D.
刊名: Journal of Biomedical Science, 1998, Vol.5 (2), pp.74-78
来源数据库: Karger
DOI: 10.1159/000025315
关键词: Tyrosine kinasesSerine kinasesRT-PCRDifferential displayDegenerate primersKinase display
原始语种摘要: As the post-genome era is approaching, with vast amount of sequence information available and new technology developed, scientists are presented with opportunities to explore in simple analysis the structure and expression pattern of not just a single gene, but of an entire family of genes, if not the entire genome. The concept of ‘molecular profiling’ or ‘expression array’ has thus emerged. The need to simultaneously ‘see’ all genes in the same family is obvious under the precept of the combinatorial process being an underlying principle of complex biological systems: no gene exists in isolation, for virtually every molecule participates in intermolecular interactions. The activation of receptor tyrosine kinases through homo or hetero-dimerization is the prototypic example. In this...
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影响因子:2.458 (2012)

  • expression 表示
  • Tyrosine 酪氨酸
  • available 可供应的
  • several 各自
  • obvious 迷的
  • genome 基因组
  • family 
  • tyrosine 酪氨酸
  • entire 完整的
  • intermolecular 分子间的