Activation of STAT Transcription Factors in Oncogenic Tyrosine Kinase Signaling
作者: Garcia R.Jove R.
刊名: Journal of Biomedical Science, 1998, Vol.5 (2), pp.79-85
来源数据库: Karger
DOI: 10.1159/000025316
关键词: STATSignal transductionTyrosine kinasesOncogenesCell growthTransformationTumorigenesis
原始语种摘要: Signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors that translocate to the nucleus and regulate gene expression in response to cytokine and growth factor stimulation. Emerging evidence indicates that STAT signaling is also frequently activated by oncogenes and in tumor cells. Constitutive activation of STAT proteins has been reported in cell lines stably transformed by diverse oncoproteins that directly or indirectly activate specific tyrosine kinase signaling pathways. In addition, STAT activation has been detected in a variety of human tumors and tumor cell lines, many of which are known to harbor activated tyrosine kinases. Recent findings support a model in which activation of STAT signaling in the context of oncogenesis induces gene...
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影响因子:2.458 (2012)

  • STAT 静止的
  • translocate 移位
  • activate 活化
  • Tyrosine 酪氨酸
  • activation 活化
  • transcription 地名转写
  • stimulation 激励
  • oncogenesis 肿瘤发生
  • cytoplasmic 细胞质的
  • signaling 发信号