Brain Perfusion in Autism Varies with Age
作者: Wilcox J.Tsuang M.T.Ledger E.Algeo J.Schnurr T.
刊名: Neuropsychobiology, 2002, Vol.46 (1), pp.13-16
来源数据库: Karger
DOI: 10.1159/000063570
关键词: AutismPerfusionSPECT
原始语种摘要: Oursubjects consisted of 14 autistic individuals and 14 controls ranging in age from 3 to 37 years. A 99mTc HMPAO single photon emission computed tomogram (SPECT) was used to examine blood flow variations between autistic subjects, compared to an age- and gender-matched control group. We found significant hypoperfusion in the prefrontal areas of autistic individuals as compared to normals in every case (p < 0.01). As the age of the autistic individuals increased the hypoperfusion of verbal-associated areas in the left temporal lobe and frontal areas became more evident. The findings were significant at the p < 0.001 level. The changes in perfusion over time correlated with language development and acquisition as individuals matured. We conclude that autistic individuals have a...
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影响因子:2.371 (2012)

  • autistic 我向的
  • prefrontal 前额骨
  • hypoperfusion 灌注不足
  • associated 相关的
  • temporal 现世的
  • development 开发
  • gender 性别
  • matched 匹配的
  • significant 有效的
  • fluency 流畅