MeOH Fraction from Beneficial Microorganisms Fermented Product Promotes the Expression of Th1 (IFN-γ) Cytokine and Decreases Expression of Th2 Cytokines in C57BL/6 Mice
作者: Myungwon Choi Kwang Hyuk Kim Insoo Shim Sung-Cheol Koh In-Soo Kim Sun-Young Lim
刊名: The Philippine Agricultural Scientist, 2015, Vol.98 (4)
来源数据库: College of Agriculture, University of the Philippines Los Baños
关键词: anti-inflammationbeneficial microorganisms (BM)cytokinestype 1 helper T celltype 2 helper T cell
原始语种摘要: We investigated the effect of a beneficial microorganisms (BM) fermented product on the induction of cytokines in C57BL/6 mice. The culture supernatants of splenocytes exposed to 85% aqueous methanol (85% aq. MeOH) fraction from the BM product plus concanavalin A (Con A) were harvested to determine the production of Th1 (IFN-γ, TNF-α, IL-2, IL-17A) and Th2 [IL-4, IL-5, IL-6, IL-10, IL-12/IL-23(p40)] cytokines. Cytokines were measured using enzyme-linked immunosorbent assay (ELISA) reader. Co-administration of the 85% aq. MeOH fraction with Con A resulted in a significantly higher IFN-γ expression than that observed with Con A alone (P < 0.01), but significantly decreased TNF-α and IL-17A expression (P<0.05). Treatment with 85% aq. MeOH fraction plus Con A also significantly decreased the...
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  • cytokines 细胞浆移动
  • IFN 伊斯法罕
  • immunosorbent 免疫吸收剂
  • fraction 分数
  • expression 表示
  • concanavalin 伴刀豆球蛋白
  • significantly 较大地
  • potential 
  • product 产物
  • modulating 调制的