Bacteriophages and a homology model of a large terminase bacteriophage protein
作者: Brittany GrenyerMorgan SperratoreMelinda Harrison
刊名: Journal of Biotech Research, 2018(9)
来源数据库: Bio Tech System
原始语种摘要: A bacteriophage is a virus that is able to infect and replicate inside a bacterium host. Catdawg is a mycobacteriophage belonging to Cluster O and the siphoviridae family. GP30, the large terminase protein of Catdawg, is responsible for the cleavage of the DNA and its translocation into the procapsid. There are two components of the large terminase protein which include the ATPase domain and the nuclease domain. The structure of GP30, the large terminase protein is unknown and the amount of structural information on phages is limited. In this study, homology modeling of GP30 was performed and the model was then compared to known crystal structures. The top result was a DNA packaging protein, GP-17 from bacteriophage T4. The predicted structure was then validated using Procheck. These...
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关键词翻译
关键词翻译
  • bacteriophage 噬菌体
  • protein 蛋白质
  • large 大的
  • procapsid 原壳体
  • homology 同源
  • known 己知
  • nuclease 核酸酶
  • domain 领域
  • crystal 晶体
  • conformation 构象