Characterization of the adult Aedes aegypti early midgut peritrophic matrix proteome using LC-MS
作者: Shavonn R. WhitenW. Keith RayRichard F. HelmZach N. Adelman
作者单位: 11 Department of Entomology, Texas A&M University, College Station, Texas, United States of America
2 2 Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
刊名: PLOS ONE, 2018, Vol.13 (3)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0194734
原始语种摘要: The Aedes aegypti mosquito is the principal vector of arboviruses such as dengue, chikungunya, yellow fever, and Zika virus. These arboviruses are transmitted during adult female mosquito bloodfeeding. While these viruses must transverse the midgut to replicate, the blood meal must also reach the midgut to be digested, absorbed, or excreted, as aggregation of blood meal metabolites can be toxic to the female mosquito midgut. The midgut peritrophic matrix (PM), a semipermeable extracellular layer comprised of chitin fibrils, glycoproteins, and proteoglycans, is one such mechanism of protection for the mosquito midgut. However, this structure has not been characterized for adult female Ae . aegypti . We conducted a mass spectrometry based proteomic analysis to identify proteins that...
全文获取路径: PLOS  (合作)
影响因子:3.73 (2012)

  • midgut 中肠
  • adult 成体
  • proteins 蛋白质
  • early 
  • female 女性的
  • available 可供应的
  • observed 观察到的
  • salivary 唾液的
  • several 各自
  • known 己知