Space-Time Clustering of Childhood Leukemia: Evidence of an Association with ETV6-RUNX1 (TEL-AML1) Fusion
| 作者： | Christian Kreis, Judith E. Lupatsch, Felix Niggli, Matthias Egger, Claudia E. Kuehni, Ben D. Spycher |
| 作者单位： |
11 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland 2 2 University Children's Hospital Zurich, Zurich, Switzerland |
| 刊名： | PLOS ONE, 2017, Vol.12 (1) |
| 来源数据库： | PLOS |
| DOI： | 10.1371/journal.pone.0170020 |
| 原始语种摘要： | Many studies have observed space-time clustering of childhood leukemia (CL) yet few have attempted to elicit etiological clues from such clustering. We recently reported space-time clustering of CL around birth, and now aim to generate etiological hypotheses by comparing clustered and nonclustered cases. We also investigated whether the clustering resulted from many small aggregations of cases or from a few larger clusters.;;We identified cases of persons born and diagnosed between 1985 and 2014 at age 0–15 years from the Swiss Childhood Cancer Registry. We determined spatial and temporal lags that maximized evidence of clustering based on the Knox test and classified cases born within these lags from another case as clustered. Using logistic regression adjusted for child population... |
