Space-Time Clustering of Childhood Leukemia: Evidence of an Association with ETV6-RUNX1 (TEL-AML1) Fusion
作者: Christian KreisJudith E. LupatschFelix NiggliMatthias EggerClaudia E. KuehniBen D. Spycher
作者单位: 11 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland
2 2 University Children's Hospital Zurich, Zurich, Switzerland
刊名: PLOS ONE, 2017, Vol.12 (1)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0170020
原始语种摘要: Many studies have observed space-time clustering of childhood leukemia (CL) yet few have attempted to elicit etiological clues from such clustering. We recently reported space-time clustering of CL around birth, and now aim to generate etiological hypotheses by comparing clustered and nonclustered cases. We also investigated whether the clustering resulted from many small aggregations of cases or from a few larger clusters.;;We identified cases of persons born and diagnosed between 1985 and 2014 at age 0–15 years from the Swiss Childhood Cancer Registry. We determined spatial and temporal lags that maximized evidence of clustering based on the Knox test and classified cases born within these lags from another case as clustered. Using logistic regression adjusted for child population...
全文获取路径: PLOS  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • clustering 聚类
  • clustered 群生的
  • Association 美国公共卫生协会
  • temporal 现世的
  • Space 空格
  • Fusion 富申牌手表
  • space 宇宙
  • classified 保密的
  • interacting 相克的
  • leukemia 白血病