Inhibition of Helicobacter pylori and Its Associated Urease by Palmatine: Investigation on the Potential Mechanism
作者: Jiang-Tao ZhouCai-Lan LiLi-Hua TanYi-Fei XuYu-Hong LiuZhi-Zhun MoYao-Xing DouRui SuZi-Ren SuPing HuangJian-Hui Xie
作者单位: 11 Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, PR China
2 2 The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, PR China
3 3 Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, PR China
刊名: PLOS ONE, 2017, Vol.12 (1)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0168944
原始语种摘要: In this paper, we evaluated the anti- Helicobacter pylori activity and the possible inhibitory effect on its associated urease by Palmatine (Pal) from Coptis chinensis , and explored the potential underlying mechanism. Results indicated that Pal exerted inhibitory effect on four tested H . pylori strains (ATCC 43504, NCTC 26695, SS1 and ICDC 111001) by the agar dilution test with minimum inhibitory concentration (MIC) values ranging from 100 to 200 μg/mL under neutral environment (pH 7.4), and from 75 to 100 μg/mL under acidic conditions (pH 5.3), respectively. Pal was observed to significantly inhibit both H . pylori urease (HPU) and jack bean urease (JBU) in a dose-dependent manner, with IC50 values of 0.53 ± 0.01 mM and 0.03 ± 0.00 mM, respectively, as compared with...
全文获取路径: PLOS  (合作)
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来源刊物:
影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • urease 尿素酶
  • Helicobacter 哈比特属
  • inhibitory 禁止的
  • sulfhydryl 氢硫基
  • interact 交互作用
  • dilution 稀度
  • potentially 可能地
  • essential 本质的
  • inhibition 抑制
  • obligatory 强制性的