Evidence supporting a role for astrocytes in the regulation of cognitive flexibility and neuronal oscillations through the Ca<sup>2+</sup> binding protein S100β
作者: Adam T. BrockettGary A. KanePatrick K. MonariBrandy A. BrionesPierre-Antoine VigneronGabriela A. BarberAndres BermudezUma DieffenbachAlexander D. KlothTimothy J. BuschmanElizabeth Gould
作者单位: 11 Princeton Neuroscience Institute and Department of Psychology, Princeton University, Princeton, NJ, United States of America
2 2 Department of Cell Biology and Physiology and Neuroscience Center University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America
刊名: PLOS ONE, 2018, Vol.13 (4)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0195726
原始语种摘要: The medial prefrontal cortex (mPFC) is important for cognitive flexibility, the ability to switch between two task-relevant dimensions. Changes in neuronal oscillations and alterations in the coupling across frequency ranges have been correlated with attention and cognitive flexibility. Here we show that astrocytes in the mPFC of adult male Sprague Dawley rats, participate in cognitive flexibility through the astrocyte-specific Ca2+ binding protein S100β, which improves cognitive flexibility and increases phase amplitude coupling between theta and gamma oscillations. We further show that reduction of astrocyte number in the mPFC impairs cognitive flexibility and diminishes delta, alpha and gamma power. Conversely, chemogenetic activation of astrocytic intracellular...
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • 星形细胞 有关联的
  • flexibility 柔顺性
  • sup 吃晚饭
  • cognitive 修]认知[识
  • through 经过
  • protein 蛋白质
  • regulation 
  • neuronal 二乙基溴乙酰胺
  • binding 装订
  • relevant 有关联的
  • astrocyte 有关联的