Long disordered regions of the C-terminal domain of Abelson tyrosine kinase have specific and additive functions in regulation and axon localization
作者: Han S. J. CheongMark F. A. VanBerkum
作者单位: 1Department of Biological Sciences, Wayne State University, Detroit, United States of America
刊名: PLOS ONE, 2017, Vol.12 (12)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0189338
原始语种摘要: Abelson tyrosine kinase (Abl) is a key regulator of actin-related morphogenetic processes including axon guidance, where it functions downstream of several guidance receptors. While the long C-terminal domain (CTD) of Abl is required for function, its role is poorly understood. Here, a battery of mutants of Drosophila Abl was created that systematically deleted large segments of the CTD from Abl or added them back to the N-terminus alone. The functionality of these Abl transgenes was assessed through rescue of axon guidance defects and adult lethality in Abl loss-of-function, as well as through gain-of-function effects in sensitized slit or frazzled backgrounds that perturb midline guidance in the Drosophila embryonic nerve cord. Two regions of the CTD play important and distinct roles,...
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • disordered 混乱的
  • tyrosine 酪氨酸
  • additive 添加剂
  • domain 领域
  • required 必需
  • regulation 
  • typically 典型地
  • guidance 制导
  • distinct 相异的
  • terminus 末端