17β-Estradiol and/or estrogen receptor alpha signaling blocks protein phosphatase 1 mediated ISO induced cardiac hypertrophy
作者: Hsin-Yuan FangMeng-Yu HungYueh-Min LinSudhir PandeyChia-Chien ChangKuan-Ho LinChia-Yao ShenVijaya Padma ViswanadhaWei-Wen KuoChih-Yang Huang
作者单位: 11 Department of Thoracic Surgery, China Medical University Hospital, Taichung, Taiwan
2 2 Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
3 3 Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan
4 4 Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan
5 5 Department of Dermatology, Taipei City Hospital, Renai Branch, Taipei, Taiwan
6 6 Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan
7 7 Department of Nursing, Meiho University, Pingtung, Taiwan
8 8 Department of Biotechnology, Bharathiar University, Coimbatore, India
9 9 Department of Biological Science and Technology, China Medical University, Taichung, Taiwan
10 10 Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
11 11 Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan
刊名: PLOS ONE, 2018, Vol.13 (5)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0196569
原始语种摘要: Earlier studies have shown that estrogen possess protective function against the development of pathological cardiac hypertrophy. However, the molecular mechanisms of estrogens (E2) protective effect are poorly understood. Additionally, abnormal activation of β-adrenergic signaling have been implicated in the development of pathological cardiac remodeling. However, the role of serine/threonine protein phosphatase 1 (PP1) in pathological cardiac remodeling under the influence of β-adrenergic signaling have been sparsely investigated. In this study, we assessed the downstream effects of abnormal activation of PP1 upon isoproterenol (ISO) induced pathological cardiac changes. We found that pre-treatment of 17β-estradiol (E2), tet-on estrogen receptor-α, or both significantly inhibited...
全文获取路径: PLOS  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • estrogen 雌激素
  • induced 感应的
  • hypertrophy 肥大
  • receptor 接受体
  • protein 蛋白质
  • pathological 病理学的
  • signaling 发信号
  • alpha 接字母顺序的
  • melatonin 褪黑激素
  • phosphatase 磷酸酶