Killer-cell immunoglobulin-like receptors associate with HIV-1 infection in a narrow-source Han Chinese cohort
作者: Linghang WangYonghong ZhangKeyi XuTao DongSarah Rowland-JonesLouis-Marie Yindom
作者单位: 11 Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China
2 2 Nuffield Department of Medicine, Headington, Oxford, United Kingdom
3 3 MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
4 4 Beijing You An Hospital, Capital Medical University, Beijing, People's Republic of China
刊名: PLOS ONE, 2018, Vol.13 (4)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0195452
原始语种摘要: The HIV pandemic remains the most serious challenge to public health worldwide. The hallmark characteristics of the disease is the eventual failure of the immune system to control opportunistic infections and death. However not everyone who has HIV develops the disease at the same rate and so we are studying how the immune system works to control the virus in those who have been infected for decades and remain relatively healthy without the need of anti-retroviral therapy (ART).;;Genomic DNA samples from 513 Chinese Han individuals from Henan province were typed for 15 KIR and 3 HLA class I genes. Genotype frequencies were compared between a village cohort of 261 former plasma donors (SM cohort) infected with HIV-1 through an illegal plasma donor scheme who survived more than 10 years of...
全文获取路径: PLOS  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • immunoglobulin 免疫球蛋白
  • HIV Hydraulic Isolation Valve
  • cohort 伙伴
  • infection 感染
  • controls 控制机构
  • remains 残渣
  • eventual 可能发生的
  • associate 使联合
  • immune 免疫的
  • infected 被感染