Pharmacokinetic properties of a novel inosine analog, 4′-cyano-2′-deoxyinosine, after oral administration in rats
作者: Mai HashimotoKazuaki TaguchiTakako IshiguroSatoru KohgoShuhei ImotoKeishi YamasakiHiroaki MitsuyaMasaki Otagiri
作者单位: 11 Faculty of Pharmaceutical Sciences, Sojo University, Ikeda, Kumamoto, Japan
2 2 Center for Clinical Sciences, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan
3 3 DDS Research Institutes, Sojo University, Ikeda, Kumamoto, Japan
4 4 Department of Infectious Diseases and Hematology, Kumamoto University, School of Medicine, Kumamoto, Japan
5 5 Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
刊名: PLOS ONE, 2018, Vol.13 (6)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0198636
原始语种摘要: 4′-cyano-2′-deoxyinosine (SK14-061a), a novel nucleoside analog based on inosine, has antiviral activity against the human immunodeficiency virus type 1 that has the ability to acquire resistance against many types of reverse transcriptase inhibitors based on nucleosides. The aim of this study was to investigate the pharmacokinetics studies after its oral administration to rats. For this purpose, we first developed and validated an analytical method for quantitatively determining SK14-061a levels in biological samples by a UPLC system interfaced with a TOF-MS system. A rapid, simple and selective method for the quantification of SK14-061a in biological samples was established using liquid chromatography mass spectrometry (LC-MS) with solid phase extraction. The pharmacokinetic properties...
全文获取路径: PLOS  (合作)
分享到:
来源刊物:
影响因子:3.73 (2012)

×
关键词翻译
关键词翻译
  • administration 管理
  • novel 长篇小说
  • nucleoside 核苷
  • analog 相似体
  • against 反对
  • properties 道具
  • unchanged 未改变的
  • biological 生物学的
  • pharmaceutical 
  • transcriptase 转录酶