Stage-Specific MicroRNAs and Their Role in the Anticancer Effects of Calorie Restriction in a Rat Model of ER-Positive Luminal Breast Cancer
作者: Kaylyn L. DevlinTiffany SanfordLauren M. HarrisonPaul LeBourgeoisLaura M. LashingerElizabeth MamboStephen D. Hursting
作者单位: 11 Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America
2 2 Asuragen Incorporated, Austin, Texas, United States of America
3 3 Department of Nutritional Sciences, The University of Texas at Austin, Austin, Texas, United States of America
刊名: PLOS ONE, 2016, Vol.11 (7)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0159686
原始语种摘要: MicroRNAs have emerged as ubiquitous post-transcriptional regulators that coordinate many fundamental processes within cells, including those commonly linked to cancer when dysregulated. Profiling microRNAs across stages of cancer progression provides focus as to which microRNAs are key players in cancer development and are therefore important to manipulate with interventions to delay cancer onset and progression. Calorie restriction is one of the most effective preventive interventions across many types of cancer, although its effects on microRNAs have not been well characterized. We used the dimethylbenz[a]-anthracene-induced model of luminal mammary cancer in Sprague Dawley rats to elucidate which microRNAs are linked to progression in this type of cancer and, subsequently, to study...
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • restriction 限制
  • mammary 乳房的
  • cancer 癌症
  • luminal 鲁米那
  • progression 级数
  • preventive 预防性
  • Cancer 巨蟹座
  • associated 相关的
  • survival 生存
  • findings 结论