C5a and C5aR are elevated in joints of rheumatoid and psoriatic arthritis patients, and C5aR blockade attenuates leukocyte migration to synovial fluid
作者: Lars HornumAnker Jon HansenDitte TornehaveMarianne Scheel FjordingPaula ColmeneroInger Falbe WätjenNiels Henrik Søe NielsenHenning BliddalElse Marie Bartels
作者单位: 11 Novo Nordisk A/S, Måløv, Denmark
2 2 Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
3 3 The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Frederiksberg, Denmark
4 4 Hand Section, Department of Orthopaedics, Herlev and Gentofte Hospital, Gentofte, Denmark
5 5 Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
刊名: PLOS ONE, 2017, Vol.12 (12)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0189017
原始语种摘要: Complement activation correlates to rheumatoid arthritis disease activity, and increased amounts of the complement split product C5a is observed in synovial fluids from rheumatoid arthritis patients. Blockade of C5a or its receptor (C5aR) is efficacious in several arthritis models. The aim of this study was to investigate the role of C5a and C5aR in human rheumatoid arthritis and psoriatic arthritis–both with respect to expression and function. Synovial fluid, blood and synovial samples were obtained from rheumatoid arthritis, psoriatic arthritis and osteoarthritis patients as a less inflammatory arthritis type, and blood from healthy subjects. Cells infiltrating synovial tissue were analysed by immunohistochemistry and flow cytometry. SF and blood were analysed for biomarkers by flow...
全文获取路径: PLOS  (合作)
影响因子:3.73 (2012)

  • arthritis 关节炎
  • rheumatoid 患风湿病的
  • synovial 关节的
  • psoriatic 牛皮癣的
  • migration 迁移
  • synovium 滑膜
  • elevated 高的
  • inflammatory 激怒的
  • infiltrating 浸润的
  • increased 增加