3D diffusion model within the collagen apatite porosity: An insight to the nanostructure of human trabecular bone
作者: Fabiano BiniAndrada PicaAndrea MarinozziFranco Marinozzi
作者单位: 11 Department of Mechanical and Aerospace Engineering, “Sapienza” University of Rome, Rome, Italy
2 2 Orthopedy and Traumatology Area, “Campus Bio-Medico” University, Rome, Italy
刊名: PLOS ONE, 2017, Vol.12 (12)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0189041
原始语种摘要: Bone tissue at nanoscale is a composite mainly made of apatite crystals, collagen molecules and water. This work is aimed to study the diffusion within bone nanostructure through Monte-Carlo simulations. To this purpose, an idealized geometric model of the apatite-collagen structure was developed. Gaussian probability distribution functions were employed to design the orientation of the apatite crystals with respect to the axes (length L, width W and thickness T) of a plate-like trabecula. We performed numerical simulations considering the influence of the mineral arrangement on the effective diffusion coefficient of water. To represent the hindrance of the impermeable apatite crystals on the water diffusion process, the effective diffusion coefficient was scaled with the tortuosity, the...
全文获取路径: PLOS  (合作)
影响因子:3.73 (2012)

  • apatite 磷灰石
  • collagen 胶骨硬蛋白质
  • diffusion 扩散
  • trabecular 小梁的
  • porosity 孔隙率
  • within 在以内
  • tortuosity 弯曲度
  • insight 识别力
  • orientation 定向
  • hindrance 干扰