Shortening intradermal rabies post-exposure prophylaxis regimens to 1 week: Results from a phase III clinical trial in children, adolescents and adults
作者: Phirangkul KerdpanichPornthep ChanthavanichMari Rose De Los ReyesJodor LimDelia YuMa. Cecilia AmaZenaida MojaresDaniela CasulaAshwani Kumar AroraMichele Pellegrini
作者单位: 11 Department of Pediatrics, Division of Infectious Diseases, Phramongkutklao Hospital, Bangkok, Thailand
2 2 Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3 3 Research Institute for Tropical Medicine, Filinvest Corporate City, Alabang Muntinlupa City, the Philippines
4 4 Asian Hospital and Medical Center, Filinvest Corporate City, Alabang Muntinlupa City, the Philippines
5 5 De La Salle Health Sciences Institute-Congressional Road, Dasmarinas City, Cavite, the Philippines
6 6 GSK, Siena, Italy
刊名: PLOS Neglected Tropical Diseases, 2018, Vol.12 (6)
来源数据库: PLOS
DOI: 10.1371/journal.pntd.0006340
原始语种摘要: This phase III clinical trial compared the immunogenicity and safety of a purified chick-embryo cell rabies vaccine (PCECV) administered according to a shortened post-exposure prophylaxis (PEP) 4-site/1-week intradermal regimen, compared with the currently recommended 2-site/Thai Red Cross (TRC).;;This controlled, open-label, multi-center study (NCT02177032) enrolled healthy individuals ≥1 year of age, randomized into 4 groups to receive intradermal PCECV according to one of the 2 regimens, with or without human rabies immunoglobulin (HRIG) administration at first visit (in adults only). Rabies virus neutralizing antibody (RVNA) concentrations and percentages of participants with RVNA concentrations ≥0.5 IU/mL (considered as adequate concentrations following PEP) were assessed up to day...
全文获取路径: PLOS  (合作)
影响因子:4.569 (2012)

  • intradermal 皮内的
  • rabies 狂犬病
  • vaccination 注射疫苗
  • prophylaxis 预防
  • immunogenicity 致免疫性
  • neutralizing 中和
  • inferiority 下等
  • regimen 生活制度
  • immunoglobulin 免疫球蛋白
  • concentrations 浓聚物