Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori -induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use
作者: Bryony N. ParsonsUmer Z. IjazRosalinda D’AmoreMichael D. BurkittRichard EcclesLuca LenziCarrie A. DuckworthAndrew R. MooreLaszlo TiszlaviczAndrea VarroNeil HallD. Mark Pritchard
作者单位: 11 Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UNITED KINGDOM
2 2 Department of Infrastructure and Environment University of Glasgow, School of Engineering, Glasgow, UNITED KINGDOM
3 3 Centre for Genomic Research, Institute of Integrative Biology, University of Liverpool, Liverpool, UNITED KINGDOM
4 4 Department of Gastroenterology, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UNITED KINGDOM
5 5 Department of Pathology, University of Szeged, Szeged, HUNGARY
6 6 The Earlham Institute, Norwich Research Park, Norwich, UNITED KINGDOM
7 7 School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk, UNITED KINGDOM
刊名: PLOS Pathogens, 2017, Vol.13 (11)
来源数据库: PLOS
DOI: 10.1371/journal.ppat.1006653
原始语种摘要: Several conditions associated with reduced gastric acid secretion confer an altered risk of developing a gastric malignancy. Helicobacter pylori- induced atrophic gastritis predisposes to gastric adenocarcinoma, autoimmune atrophic gastritis is a precursor of type I gastric neuroendocrine tumours, whereas proton pump inhibitor (PPI) use does not affect stomach cancer risk. We hypothesised that each of these conditions was associated with specific alterations in the gastric microbiota and that this influenced subsequent tumour risk. 95 patients (in groups representing normal stomach, PPI treated, H . pylori gastritis, H . pylori- induced atrophic gastritis and autoimmune atrophic gastritis) were selected from a cohort of 1400. RNA extracted from gastric corpus biopsies was analysed using...
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影响因子:8.136 (2012)

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关键词翻译
关键词翻译
  • atrophic 萎缩的
  • gastritis 胃炎
  • gastric 胃的
  • Helicobacter 哈比特属
  • microbiota 微生物区系
  • autoimmune 自身免疫的
  • induced 感应的
  • stomach 
  • neuroendocrine 神经内分泌的
  • treated 加工的