Selection for avian leukosis virus integration sites determines the clonal progression of B-cell lymphomas
作者: Sanandan MalhotraShelby WinansGary LamJames JusticeRobin MorganKaren Beemon
作者单位: 11 Department of Biology, Johns Hopkins University, Baltimore, Maryland, United States of America
2 2 Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America
刊名: PLOS Pathogens, 2017, Vol.13 (11)
来源数据库: PLOS
DOI: 10.1371/journal.ppat.1006708
原始语种摘要: Avian leukosis virus (ALV) is a simple retrovirus that causes a wide range of tumors in chickens, the most common of which are B-cell lymphomas. The viral genome integrates into the host genome and uses its strong promoter and enhancer sequences to alter the expression of nearby genes, frequently inducing tumors. In this study, we compare the preferences for ALV integration sites in cultured cells and in tumors, by analysis of over 87,000 unique integration sites. In tissue culture we observed integration was relatively random with slight preferences for genes, transcription start sites and CpG islands. We also observed a preference for integrations in or near expressed and spliced genes. The integration pattern in cultured cells changed over the course of selection for oncogenic...
全文获取路径: PLOS  (合作)
影响因子:8.136 (2012)

  • integration 集成
  • observed 观察到的
  • leukosis 造白细胞组织增生
  • cultured 人工培养的
  • virus 病毒
  • random 随机的
  • expression 表示
  • genome 基因组
  • expressed 榨出的
  • proviral 前病毒的