Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells
作者: Minseung ChoiDiane P. GenereuxJamie GoodsonHaneen Al-AzzawiShannon Q. AllainNoah SimonStan PalasekCarol B. WareChris CavanaughDaniel G. MillerWinslow C. JohnsonKevin D. SinclairReinhard StögerCharles D. Laird
作者单位: 11 Department of Biology, University of Washington, Seattle, Washington, United States of America
2 2 Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America
3 3 Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America
4 4 Department of Pathology, University of Washington School of Medicine, Seattle, Washington, United States of America
5 5 School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire, United Kingdom
6 6 Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
7 7 Department of Mathematics, Princeton University, Princeton, New Jersey, United States of America
8 8 Department of Comparative Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
9 9 Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washing
刊名: PLOS Genetics, 2017, Vol.13 (11)
来源数据库: PLOS
DOI: 10.1371/journal.pgen.1007060
原始语种摘要: In storing and transmitting epigenetic information, organisms must balance the need to maintain information about past conditions with the capacity to respond to information in their current and future environments. Some of this information is encoded by DNA methylation, which can be transmitted with variable fidelity from parent to daughter strand. High fidelity confers strong pattern matching between the strands of individual DNA molecules and thus pattern stability over rounds of DNA replication; lower fidelity confers reduced pattern matching, and thus greater flexibility. Here, we present a new conceptual framework, Ratio of Concordance Preference (RCP), that uses double-stranded methylation data to quantify the flexibility and stability of the system that gave rise to a given set of...
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影响因子:8.517 (2012)

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关键词翻译
关键词翻译
  • methylation 甲基化酌
  • inversely 相反地
  • cells 麻风细胞
  • potential 
  • correlated 相关
  • epigenetic 后成的
  • concordant 地层整合的
  • mammalian 哺乳动物
  • developmental 试验性的
  • information 报告