Cardiovascular disease (CVD) and chronic kidney disease (CKD) event rates in HIV-positive persons at high predicted CVD and CKD risk: A prospective analysis of the D:A:D observational study
作者: Mark A. BoydAmanda MocroftLene RyomAntonella d’Arminio MonforteCaroline SabinWafaa M. El-SadrCamilla Ingrid HatlebergStephane De WitRainer WeberEric FontasAndrew PhillipsFabrice BonnetPeter ReissJens LundgrenMatthew Law
作者单位: 11 Kirby Institute, University of New South Wales, Sydney, Australia
2 2 Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia
3 3 Department of Infection and Population Health, University College London, London, United Kingdom
4 4 Centre of Excellence for Health, Immunity and Infections, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
5 5 Dipartimento di Scienze della Salute, Clinica di Malattie Infettive e Tropicali, Azienda Ospedaliera–Polo Universitario San Paolo, Milan, Italy
6 6 ICAP at Columbia University, New York, New York, United States of America
7 7 Division of Infectious Diseases, Saint-Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium
8 8 Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
9 9 Department of Public Health, Nice University Hospital, Nice, France
10 10 Centre Hospitalier Unive
刊名: PLOS Medicine, 2017, Vol.14 (11)
来源数据库: PLOS
DOI: 10.1371/journal.pmed.1002424
原始语种摘要: The Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study has developed predictive risk scores for cardiovascular disease (CVD) and chronic kidney disease (CKD, defined as confirmed estimated glomerular filtration rate [eGFR] ≤ 60 ml/min/1.73 m2) events in HIV-positive people. We hypothesized that participants in D:A:D at high (>5%) predicted risk for both CVD and CKD would be at even greater risk for CVD and CKD events.;;We included all participants with complete risk factor (covariate) data, baseline eGFR > 60 ml/min/1.73 m2, and a confirmed (>3 months apart) eGFR < 60 ml/min/1.73 m2 thereafter to calculate CVD and CKD risk scores. We calculated CVD and CKD event rates by predicted 5-year CVD and CKD risk groups (≤1%, >1%–5%, >5%) and fitted...
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影响因子:15.253 (2012)

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关键词翻译
关键词翻译
  • 预言 乘法的
  • CKD ChecKing Operator
  • CVD Chemical Vapor Deposition
  • predicted 预先计算的
  • event 事件
  • HIV Hydraulic Isolation Valve
  • rates 地方税
  • ascertainment 确定
  • multiplicative 乘法的
  • predictive 乘法的
  • observational 观察的