SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility
作者: Yi-Ru ShenHan-Yu WangYung-Che KuoShih-Chuan ShihChun-Hua HsuYet-Ran ChenShang-Rung WuChia-Yih WangPao-Lin Kuo
作者单位: 11 Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
2 2 Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
3 3 Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan
4 4 Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan
5 5 Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan
6 6 Institute of Oral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
7 7 Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
8 8 The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
刊名: PLOS Genetics, 2017, Vol.13 (3)
来源数据库: PLOS
DOI: 10.1371/journal.pgen.1006631
原始语种摘要: Septins are critical for numerous cellular processes through the formation of heteromeric filaments and rings indicating the importance of structural regulators in septin assembly. Several posttranslational modifications (PTMs) mediate the dynamics of septin filaments in yeast. However, little is known about the role of PTMs in regulating mammalian septin assembly, and the in vivo significance of PTMs on mammalian septin assembly and function remains unknown. Here, we showed that SEPT12 was phosphorylated on Ser198 using mass spectrometry, and we generated SEPT12 phosphomimetic knock-in (KI) mice to study its biological significance. The homozygous KI mice displayed poor male fertility due to deformed sperm with defective motility and loss of annulus, a septin-based ring structure....
全文获取路径: PLOS  (合作)
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影响因子:8.517 (2012)

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关键词翻译
关键词翻译
  • sperm 精子
  • annulus 体环
  • defective 有缺陷的
  • assembly 组装
  • fertility 肥度
  • importance 重要性
  • mammalian 哺乳动物
  • mediate 
  • remains 残渣
  • biogenesis 生源说