The number of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells indicates post-chemotherapy hematopoietic recovery in patients with acute myeloid leukemia
作者: Runxia GuHui WeiYing WangDong LinBingcheng LiuChunlin ZhouKaiqi LiuBenfa GongShuning WeiGuangji ZhangXiaoyuan GongYuntao LiuYan LiXingli ZhaoShaowei QiuHuijun WangMin WangYingchang MiJianxiang Wang
作者单位: 11 Department of Leukemia, Institute of Hematology, Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Tianjin, China
2 2 Department of Pathology and Lab Medicine, Institute of Hematology, Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Tianjin, China
3 3 State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
刊名: PLOS ONE, 2017, Vol.12 (7)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0180624
原始语种摘要: Hematopoietic recovery is considered to be associated with the number of multipotent hematopoietic stem cells in the bone marrow, as observed in functional assays involving stem cell transplantation. However, there is little evidence related to hematopoietic recovery in non-transplantation settings, which is accomplished by endogenous hematopoietic cells. A recent study suggested that progenitors are the main contributors during this steady-state hematopoiesis, which differs from exogenous transplantation. We hypothesized that endogenous progenitor support post-chemotherapy hematopoietic recovery. To investigate the potential impact of these progenitor cell percentage on hematopoietic recovery, we retrospectively analyzed the percentage of CD34+CD38+CD117+HLA-DR+CD13+CD33+ cells (P cells)...
全文获取路径: PLOS  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • chemotherapy 化学疗法
  • hematopoietic 补血药
  • leukemia 白血病
  • myeloid 骨髓的
  • cells 麻风细胞
  • acute 急尖的
  • recovery 回收
  • hematopoiesis 红细胞生成作用
  • remission 缓解
  • percentage 百分数