A Computational Study on the Role of Gap Junctions and Rod I <sub>h</sub> Conductance in the Enhancement of the Dynamic Range of the Retina
作者: Rodrigo PublioRodrigo F. OliveiraAntonio C. Roque
作者单位: 11 Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, Japan
2 2 Computational and Experimental Neuroplasticity Laboratory, The Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia, United States of America
3 3 Department of Physics and Mathematics, FFCLRP, University of São Paulo, Ribeirão Preto, Brazil
刊名: PLOS ONE, 2009, Vol.4 (9)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0006970
原始语种摘要: Recent works suggest that one of the roles of gap junctions in sensory systems is to enhance their dynamic range by avoiding early saturation in the first processing stages. In this work, we use a minimal conductance-based model of the ON rod pathways in the vertebrate retina to study the effects of electrical synaptic coupling via gap junctions among rods and among AII amacrine cells on the dynamic range of the retina. The model is also used to study the effects of the maximum conductance of rod hyperpolarization activated current I h on the dynamic range of the retina, allowing a study of the interrelations between this intrinsic membrane parameter with those two retina connectivity characteristics. Our results show that for realistic values of I h conductance the...
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • retina 视网膜
  • amacrine 无长突的神经细胞
  • dynamic 动力学的
  • range 射程
  • coupling 连接
  • conductance 电导
  • suggest 建议
  • vertebrate 有脊椎的
  • results 成果
  • exponent 指数