The Association of Four Common Polymorphisms from Four Candidate Genes ( COX-1 , COX-2 , ITGA2B , ITGA2 ) with Aspirin Insensitivity: A Meta-Analysis
作者: Zhiyuan WengXiaobo LiYuqiong LiJinxiu LinFeng PengWenquan Niu
作者单位: 11 Department of Cardiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
2 2 State Key Laboratory of Medical Genomics, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
3 3 Department of Hypertension, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
刊名: PLOS ONE, 2013, Vol.8 (11)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0078093
原始语种摘要: Evidence is mounting suggesting that a strong genetic component underlies aspirin insensitivity. To generate more information, we aimed to evaluate the association of four common polymorphisms (rs3842787, rs20417, rs201184269, rs1126643) from four candidate genes ( COX-1 , COX-2 , ITGA2B , ITGA2 ) with aspirin insensitivity via a meta-analysis.;;In total, there were 4 (353/595), 6 (344/698), 10 (588/878) and 7 (209/676) articles (patients/controls) qualified for rs3842787, rs20417, rs20118426 and rs1126643, respectively. The data were extracted in duplicate and analyzed by STATA software (Version 11.2). The risk estimate was expressed as odds ratio (OR) and 95% confidence interval (95% CI). Analyses of the full data set indicated significant associations of rs20417 (OR; 95% CI; P: 1.86;...
全文获取路径: PLOS  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • aspirin 阿司匹林
  • insensitivity 不灵敏度
  • Association 美国公共卫生协会
  • articles 用品
  • estimate 估计
  • observed 观察到的
  • confidence 信用
  • especially 特别地
  • allelic 等位的
  • genetic 遗传的