Placental Underperfusion in a Rat Model of Intrauterine Growth Restriction Induced by a Reduced Plasma Volume Expansion
作者: Karine BibeauBenoit SicotteMélanie BélandMenakshi BhatLouis GabouryRéjean CoutureJean St-LouisMichèle Brochu
作者单位: 11 Department of Molecular and Integrative Physiology, Université de Montréal, Montréal, Québec, Canada
2 2 Department of Pathology and Cellular Biology, Université de Montréal, Montréal, Québec, Canada
3 3 Department of Obstetrics-Gynecology, Université de Montréal, Montréal, Québec, Canada
刊名: PLOS ONE, 2016, Vol.11 (1)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0145982
原始语种摘要: Lower maternal plasma volume expansion was found in idiopathic intrauterine growth restriction (IUGR) but the link remains to be elucidated. An animal model of IUGR was developed by giving a low-sodium diet to rats over the last week of gestation. This treatment prevents full expansion of maternal circulating volume and the increase in uterine artery diameter, leading to reduced placental weight compared to normal gestation. We aimed to verify whether this is associated with reduced remodeling of uteroplacental circulation and placental hypoxia. Dams were divided into two groups: IUGR group and normal-fed controls. Blood velocity waveforms in the main uterine artery were obtained by Doppler sonography on days 14, 18 and 21 of pregnancy. On day 22 (term = 23 days), rats were sacrificed and...
全文获取路径: PLOS  (合作)
影响因子:3.73 (2012)

  • placental 胎盘的
  • maternal 母的
  • gestation 妊娠
  • restriction 限制
  • hypoxia 氧过少
  • reduced 减缩的
  • myogenic 肌原性的
  • fetal 胎的
  • increased 增加
  • uterine 子宫的