Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation
作者: Volkert A. L. HuurmanRobert HilbrandsGabriëlle G. M. PinksePieter GillardGaby DuinkerkenPieter van de LindePetronella M. W. van der Meer-PrinsMinke F. J. Versteeg-van der Voort MaarschalkKoen VerbeeckBehrooz Z. AlizadehChantal MathieuFrans K. GorusDave L. RoelenFrans H. J. ClaasBart KeymeulenDaniel G. PipeleersBart O. Roep
作者单位: 11 Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
2 2 Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
3 3 Diabetes Research Center, Brussels Free University-VUB, Brussels, Belgium
4 4 Laboratory for Experimental Medicine & Endocrinology (LEGENDO), University Hospital Gasthuisberg, Catholic University of Leuven-KUL, Leuven, Belgium
5 5 JDRF Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
刊名: PLOS ONE, 2008, Vol.3 (6)
来源数据库: PLOS
DOI: 10.1371/journal.pone.0002435
原始语种摘要: Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of recipients remains insulin–independent in the following years. We tested the hypothesis that allograft rejection and recurrent autoimmunity contribute to this progressive loss of islet allograft function.;;Twenty-one T1D patients received cultured islet cell grafts prepared from multiple donors and transplanted under anti-thymocyte globulin (ATG) induction and tacrolimus plus mycophenolate mofetil (MMF) maintenance immunosuppression. Immunity against auto- and alloantigens was measured before and during one year after transplantation. Cellular auto- and alloreactivity was assessed by lymphocyte stimulation tests against autoantigens and cytotoxic T lymphocyte precursor assays, respectively. Humoral...
全文获取路径: PLOS 
影响因子:3.73 (2012)

  • islet 
  • lymphocyte 淋巴细胞
  • insulin 胰岛素
  • autoimmunity 自体免疫
  • thymocyte 胸腺细胞
  • cytotoxic 细胞毒素的
  • allograft 同种移植
  • independence 独立性
  • immunological 免疫学的
  • remains 残渣