Screening for pulmonary arterial hypertension in systemic sclerosis
作者: Jason WeatheraldDavid MontaniMitja JevnikarXavier JaïsLaurent SavaleMarc Humbert
作者单位: 1Dept of Medicine, Division of Respirology, University of Calgary, Calgary, AB, Canada
2Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada
3Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France
4Service de Pneumologie, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France
5INSERM UMR S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
刊名: European Respiratory Review, 2019, Vol.28 (153)
来源数据库: European Respiratory Society
DOI: 10.1183/16000617.0023-2019
原始语种摘要: Pulmonary arterial hypertension (PAH) is a dreaded complication of systemic sclerosis (SSc) that occurs in ∼10% of patients. Most individuals present with severe symptoms, significant functional impairment and severe haemodynamics at diagnosis, and survival after PAH diagnosis is poor. Therefore, early diagnosis through systematic screening of asymptomatic patients has the potential to identify PAH at an early stage. Current evidence suggests that early diagnosis and treatment of PAH in patients with SSc may lead to better clinical outcomes. Annual screening may include echocardiography, but this can miss some patients due to suboptimal visualisation or insufficient tricuspid regurgitation. Other options for screening include the DETECT algorithm or the use of a combination of pulmonary...

  • arterial 动脉的
  • pulmonary 肺的
  • regurgitation 回流反流反胃
  • tricuspid 有三个尖头的
  • systemic 系统的
  • sclerosis 硬化
  • screening 筛分
  • capillaroscopy 毛细管显微镜检查
  • diffusing 扩散
  • potential