Haemodynamics and serial risk assessment in systemic sclerosis associated pulmonary arterial hypertension
作者: Jason WeatheraldAthénaïs BouclyDavid LaunayVincent CottinGrégoire PrévotDelphine BourlierClaire DauphinAri ChaouatLaurent SavaleXavier JaïsMitja JevnikarJulie TracletPascal De GrooteGérald SimonneauEric HachullaLuc MouthonDavid MontaniMarc HumbertOlivier Sitbon
作者单位: 1Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France
2APHP, Hôpital Bicêtre, Service de Pneumologie, Le Kremlin-Bicêtre, France
3INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
4Dept of Medicine, Division of Respirology, University of Calgary, Calgary, AB, Canada
5Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada
6Université Lille, U995 - LIRIC - Lille Inflammation Research International Center, Lille, France
7INSERM, U995, Lille, France
8CHU Lille, Département de Médecine Interne et Immunologie Clinique, Lille, France
9Centre de Référence des Maladies Autoimmunes et Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France
10Hospices Civils de Lyon, Dept of Respiratory Medicine, Louis Pradel Hospital, Lyon, France
11University Claude Bernard Lyon 1, University of Lyon, UMR 754, Lyon, France
12CHU de Toulouse, Hôpital Larrey, Service de Pneumologie, Toulouse, France
13Université de Bordeaux, CHU
刊名: European Respiratory Journal, 2018, Vol.52 (4)
来源数据库: European Respiratory Society
DOI: 10.1183/13993003.00678-2018
原始语种摘要: The prognostic importance of follow-up haemodynamics and the validity of multidimensional risk assessment are not well established for systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH).(#br)We assessed incident SSc-PAH patients to determine the association between clinical and haemodynamic variables at baseline and first follow-up right heart catheterisation (RHC) with transplant-free survival. RHC variables included cardiac index, stroke volume index (SVI), pulmonary arterial compliance and pulmonary vascular resistance. Risk assessment was performed according to the number of low-risk criteria: functional class I or II, 6-min walking distance (6MWD) >440 m, right atrial pressure <8 mmHg and cardiac index ≥2.5 L·min−1·m−2.(#br)Transplant-free...
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  • pulmonary 肺的
  • arterial 动脉的
  • assessment 评价
  • sclerosis 硬化
  • hypertension 高血压
  • systemic 系统的
  • associated 相关的
  • survival 生存
  • prognostic 预测的
  • variables 变量