Lung clearance index: assessment and utility in children with asthma
作者: Amy G. L. NuttallWerner VelásquezCaroline S. BeardsmoreErol A. Gaillard
作者单位: 1Institute for Lung Health, NIHR Leicester Respiratory Biomedical Research Unit and Dept of Infection Immunity and Inflammation, University of Leicester, Leicester, UK
2Children's Hospital, University Hospitals Leicester, Leicester, UK
3Hospital de Especialidades Rodolfo Robles, Quetzaltenango, Guatemala
刊名: European Respiratory Review, 2019, Vol.28 (154)
来源数据库: European Respiratory Society
DOI: 10.1183/16000617.0046-2019
原始语种摘要: There is increasing evidence that ventilation heterogeneity and small airway disease are significant factors in asthma, with evidence suggesting that the small airways are involved from an early stage in childhood asthma. Spirometry is commonly used to monitor lung function in asthmatics; however, it is not sensitive to small airway disease. There has been renewed interest in multibreath washout (MBW) tests, with recognition of the lung clearance index (LCI) as a global index of abnormality in gas mixing of the lungs that therefore also reflects small airway disease. This review summarises the technical and practical aspects of the MBW/LCI in children, and the differences between commercially available equipment. Children with severe asthma are more likely to have an abnormal LCI, whereas...
全文获取路径: ERS  (合作)

  • asthma 哮喘
  • airway 航路
  • children 子女
  • assessment 评价
  • clearance 间隙
  • spirometry 肺量测定法
  • abnormality 反常
  • lungs 
  • washout 冲蚀
  • heterogeneity 不均匀性