CD8+ Tc2 cells: underappreciated contributors to severe asthma
作者: Timothy S.C. HinksRyan D. HoyleErwin W. Gelfand
作者单位: 1Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Dept of Medicine Experimental Medicine, University of Oxford, Oxford, UK
2Division of Cell Biology, Dept of Pediatrics, National Jewish Health, Denver, CO, USA
刊名: European Respiratory Review, 2019, Vol.28 (154)
来源数据库: European Respiratory Society
DOI: 10.1183/16000617.0092-2019
原始语种摘要: The complexity of asthma is underscored by the number of cell types and mediators implicated in the pathogenesis of this heterogeneous syndrome. Type 2 CD4+ T-cells (Th2) and more recently, type 2 innate lymphoid cells dominate current descriptions of asthma pathogenesis. However, another important source of these type 2 cytokines, especially interleukin (IL)-5 and IL-13, are CD8+ T-cells, which are increasingly proposed to play an important role in asthma pathogenesis, because they are abundant and are comparatively insensitive to corticosteroids. Many common triggers of asthma exacerbations are mediated via corticosteroid-resistant pathways involving neutrophils and CD8+ T-cells. Extensive murine data reveal the plasticity of CD8+ T-cells and their capacity to enhance airway...
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  • asthma 哮喘
  • eosinophilic 嗜曙红的
  • leukotriene 白细胞三烯
  • corticosteroid 皮质甾类
  • severe 严滥
  • airway 航路
  • cysteinyl 半胱氨酰基
  • bronchial 支气管的
  • pathogenesis 发病机理
  • chemotaxis 签性