Long-term outcomes of dasatinib-induced pulmonary arterial hypertension: a population-based study
作者: Jason WeatheraldMarie-Camille ChaumaisLaurent SavaleXavier JaïsAndrei SeferianMatthieu CanuetHélène BouvaistPascal MagroAnne BergeronChristophe GuignabertOlivier SitbonGérald SimonneauMarc HumbertDavid Montani
作者单位: 1Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France
2Service de Pneumologie, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France
3INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
4Division of Respirology, Dept of Medicine, University of Calgary, Calgary, AB, Canada
5Université Paris-Sud, Faculté de Pharmacie, Université Paris-Saclay, Châtenay Malabry, France
6Service de Pharmacie, DHU-TORINO, Hôpital Antoine Béclère, Clamart, France
7Service de Pneumologie, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
8Service de Cardiologie, CHU Genoble Alpes, Grenoble, France
9Service de Pneumologie, CHRU de Tours, Tours, France
10AP-HP, Hôpital Saint-Louis, Service de Pneumologie, Paris, France
11Université Paris-Diderot, Sorbonne Paris Cité, UMR 1153 CRESS, Biostatistics and Clinical Epidemiology Research Team, Paris, France
刊名: European Respiratory Journal, 2017, Vol.50 (1)
来源数据库: European Respiratory Society
DOI: 10.1183/13993003.00217-2017
原始语种摘要: This study aimed to describe the long-term outcomes of pulmonary arterial hypertension (PAH) induced by dasatinib.(#br)21 incident, right heart catheterisation-confirmed cases of dasatinib-induced PAH were identified from the French Pulmonary Hypertension Registry. Clinical and haemodynamic variables were compared from baseline to last follow-up (median (range) 24 (1–81) months).(#br)Median age was 52 years and 15 patients were female (71%). 19 patients received dasatinib for chronic myelogenous leukaemia for a median (range) duration of 42 (8–74) months before PAH diagnosis. No bone morphogenic protein receptor-2 ( BMPR2 ) mutations were found in the 10 patients tested. Dasatinib was uniformly discontinued and 11 patients received PAH medications. Four patients died during follow-up. New...
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关键词翻译
关键词翻译
  • arterial 动脉的
  • induced 感应的
  • improved 改进
  • pulmonary 肺的
  • hypertension 高血压
  • range 射程
  • therefore 因此
  • years 年代
  • follow 
  • received 接收