Metabolomics analysis identifies different metabotypes of asthma severity
作者: Stacey N. ReinkeHéctor Gallart-AyalaCristina GómezAntonio ChecaAlexander FaulandShama NazMuhammad Anas KamlehRatko DjukanovićTimothy S.C. HinksCraig E. Wheelock
作者单位: 1Division of Physiological Chemistry 2, Dept of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
2Institute of Environmental Medicine and the Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden
3Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
4Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, UK
5Dept for Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
刊名: European Respiratory Journal, 2017, Vol.49 (3)
来源数据库: European Respiratory Society
DOI: 10.1183/13993003.01740-2016
原始语种摘要: In this study, we sought to determine whether asthma has a metabolic profile and whether this profile is related to disease severity.(#br)We characterised the serum from 22 healthy individuals and 54 asthmatics (12 mild, 20 moderate, 22 severe) using liquid chromatography–high-resolution mass spectrometry-based metabolomics. Selected metabolites were confirmed by targeted mass spectrometry assays of eicosanoids, sphingolipids and free fatty acids.(#br)We conclusively identified 66 metabolites; 15 were significantly altered with asthma (p≤0.05). Levels of dehydroepiandrosterone sulfate, cortisone, cortisol, prolylhydroxyproline, pipecolate and N-palmitoyltaurine correlated significantly (p<0.05) with inhaled corticosteroid dose, and were further shifted in individuals treated with oral...
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关键词翻译
关键词翻译
  • asthma 哮喘
  • severity 严重性
  • corticosteroid 皮质甾类
  • conclusively 最后地
  • analysis 分析
  • receptor 接受体
  • severe 严滥
  • controls 控制机构
  • systemic 系统的
  • increased 增加