Airway eosinophils in older teenagers with outgrown preschool wheeze: a pilot study
作者: Lucy MarshallCaroline S. BeardsmoreAnina M. PescatoreClaudia E. KuehniErol A. Gaillard
作者单位: 1Institute for Lung Health, NIHR Leicester Respiratory Biomedical Research Unit and Dept of Infection Immunity and Inflammation, University of Leicester, Leicester, UK
2University Hospitals Leicester, Children's Hospital, Leicester UK
3Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
刊名: European Respiratory Journal, 2015, Vol.46 (5), pp.1486-1489
来源数据库: European Respiratory Society
DOI: 10.1183/13993003.00174-2015
原始语种摘要: Preschool wheezing affects one-third of all children growing up in the UK [1]. It varies in clinical presentation and severity, and there is evidence to suggest the co-existence of different wheeze phenotypes [2], some of which have been associated with adult asthma and chronic obstructive pulmonary disease [3]. Using data from the Leicester Respiratory Cohort studies [4], we have previously applied objective data-driven methods to distinguish three distinct preschool wheeze phenotypes: “atopic” and “non-atopic” persistent wheeze (PW) and transient viral wheeze (TVW) [5]. In children with PW, attacks of wheeze with and without colds were observed both at preschool age (0–5 years) and when followed-up at early school-age (4–8 years). Children with TVW, triggered predominantly by colds, had...
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  • 子女 提示
  • wheeze 喘鸣
  • preschool 学龄前的
  • wheezing 喘鸣
  • atopic 特异反应性的
  • years 年代
  • presentation 提示
  • children 提示
  • previously 以前
  • objective 接物镜
  • pulmonary 肺的