This study investigated the health implications of work-related stress among academic staff of tertiary institutions in Katsina State, Nigeria. This research adopts a descriptive survey design. The population of this study is 2,036 academic staff from thirteen institutions. A sample of 328 academic staff was drawn, using proportionate stratified sampling technique. A self-developed questionnaire (HIWRS-Q) with reliability of 0.75 was used. Chi-square and t-test were used to test the hypotheses at 0.05 level of significance. Findings of this study revealed that 105 (32%) of the respondents do not experienced health implications of work-related stress while, 223 (68%) of the respondents experienced health implications of work-related stress. Also, there is significant health implication of... work-related stress among academic staff (P=0.001<0.05). There is significant difference in the health implication of work-related stress among academic staff based on institutional ownership (P=0.023<0.05). There is no significant difference in the work-related stress between male and female teaching staff (P=0.650>0.05). It is recommended among others that the State government should improve on the working environment and conditions of academic staff to be health-friendly, health enhancing conditions for achieving academic excellence, and sustainable productivity in the State.