Background: In many developed countries, 70 to 80% of the population use some form of alternative or complementary medicine. Aim: The study was aimed at evaluating the phytochemical and sub acute toxicity profile of Bridelia ferruginea bark in white albino rats and subsequent inference to its probable safety/ toxicity to human use. Methods: The stem bark of Bridelia ferruginea were collected, air-dried to constant weight under shade and pulverized to powder. The phytochemical screening of the plant was done and the LD50 was also determined using standard methods. A 28 day repeat dose study was carried out using oral administration of aqueous bark extract of Bridelia ferruginea to dose four groups of rats 250mg, 500mg, 1000mg and control. Haematological and biochemical parameters were... determined to evaluate the renal and hepatic system for possible toxicity. The liver, heart, spleen, kidneys and lungs of the rats were physically examined, weighed and preserved in 10% formalin for histopathological analysis. Results: The results showed that alkaloids are the most predominantly phytochemicals present, while tannins, saponins, flavonoids, terpenes, cardiac glycosides and anthraquinones were present in moderate quantities in the bark of Bridelia ferruginea. The LD50 was estimated to be >5000mg/kg. Potassium level was significantly increased in the 1000mg group, while liver aspartate aminotransferase (AST) was significantly (P<0.05) decreased at the dose of 250mg/kg. Conclusion: It was therefore concluded that the aqueous extract of Bridelia ferruginea is relatively safe for oral use in humans.