Determination of Critical Micellar Concentration of Homologous 2-Alkoxyphenylcarbamoyloxyethyl-Morpholinium Chlorides
作者: Lenka StopkováJana GališinováZuzana ŠuchtováJozef ČižmárikFils Andriamainty
作者单位: 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojárov 10, 83232 Bratislava, Slovakia; (L.S.); (J.G.); (Z.S.); (J.C.)
刊名: Molecules, 2018, Vol.23 (5)
来源数据库: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/molecules23051064
关键词: Local anestheticMorpholinium chlorideCritical micellar concentrationPyrene absorptionSigmoidal Boltzmann equation
原始语种摘要: The critical micellar concentrations of selected alkyloxy homologues of local anesthetic 4-(2-{[(2-alkoxyphenyl)carbamoyl]oxy}ethyl)morpholin-4-ium chloride with nc = 2, 4, 5, 6, 7, 8, and 9 carbons in alkyloxy tail were determined by absorption spectroscopy in the UV–vis spectral region with the use of a pyrene probe. Within the homologous series of the studied amphiphilic compounds, the ln(cmc) was observed to be dependent linearly on the number of carbon atoms nc in the hydrophobic tail: ln(cmc) = 0.705–0.966 nc. The Gibbs free energy, necessary for the transfer of the methylene group of the alkoxy chain from the water phase into the inner part of the micelle at the temperature of 25 °C and pH ≈ 4.5–5.0, was found to be −2.39 kJ/mol. The experimentally determined cmc values showed good...
全文获取路径: MDPI  (合作)
影响因子:2.428 (2012)

  • alkoxy 烷氧基
  • chloride 氯化物
  • amphiphilic 两亲的
  • bulkiness 膨松性
  • micellar 胶束的
  • absorption 吸收
  • anesthetic 麻醉剂
  • hydrophobic 疏水的
  • micelle 胶束
  • ethyl 乙基